Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.
Identifieur interne : 003652 ( Main/Exploration ); précédent : 003651; suivant : 003653Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.
Auteurs : William Greenhalf ; Paula Ghaneh ; John P. Neoptolemos ; Daniel H. Palmer ; Trevor F. Cox ; Richard F. Lamb ; Elizabeth Garner ; Fiona Campbell ; John R. Mackey ; Eithne Costello ; Malcolm J. Moore ; Juan W. Valle ; Alexander C. Mcdonald ; Ross Carter ; Niall C. Tebbutt ; David Goldstein ; Jennifer Shannon ; Christos Dervenis ; Bengt Glimelius ; Mark Deakin ; Richard M. Charnley ; François Lacaine ; Andrew G. Scarfe ; Mark R. Middleton ; Alan Anthoney ; Christopher M. Halloran ; Julia Mayerle ; Attila Oláh ; Richard Jackson ; Charlotte L. Rawcliffe ; Aldo Scarpa ; Claudio Bassi ; Markus W. BüchlerSource :
- Journal of the National Cancer Institute [ 1460-2105 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (mortalité), Adénocarcinome (métabolisme), Adénocarcinome (traitement médicamenteux), Antinéoplasiques antimétabolites (usage thérapeutique), Désoxycytidine (analogues et dérivés), Désoxycytidine (usage thérapeutique), Estimation de Kaplan-Meier, Europe (épidémiologie), Femelle, Fluorouracil (administration et posologie), Humains, Leucovorine (administration et posologie), Marqueurs biologiques tumoraux (métabolisme), Mâle, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Survie sans rechute, Transporteur équilibrant de nucléosides de type 1 (métabolisme), Tumeurs du pancréas (mortalité), Tumeurs du pancréas (métabolisme), Tumeurs du pancréas (traitement médicamenteux).
- MESH :
- administration et posologie : Fluorouracil, Leucovorine.
- analogues et dérivés : Désoxycytidine.
- mortalité : Adénocarcinome, Tumeurs du pancréas.
- métabolisme : Adénocarcinome, Marqueurs biologiques tumoraux, Transporteur équilibrant de nucléosides de type 1, Tumeurs du pancréas.
- traitement médicamenteux : Adénocarcinome, Tumeurs du pancréas.
- usage thérapeutique : Antinéoplasiques antimétabolites, Désoxycytidine, Protocoles de polychimiothérapie antinéoplasique.
- épidémiologie : Europe.
- Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Survie sans rechute.
English descriptors
- KwdEn :
- Adenocarcinoma (drug therapy), Adenocarcinoma (metabolism), Adenocarcinoma (mortality), Adult, Aged, Antimetabolites, Antineoplastic (therapeutic use), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Biomarkers, Tumor (metabolism), Deoxycytidine (analogs & derivatives), Deoxycytidine (therapeutic use), Disease-Free Survival, Equilibrative Nucleoside Transporter 1 (metabolism), Europe (epidemiology), Female, Fluorouracil (administration & dosage), Humans, Kaplan-Meier Estimate, Leucovorin (administration & dosage), Male, Middle Aged, Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (metabolism), Pancreatic Neoplasms (mortality), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Fluorouracil, Leucovorin.
- chemical , analogs & derivatives : Deoxycytidine.
- chemical , metabolism : Biomarkers, Tumor, Equilibrative Nucleoside Transporter 1.
- chemical , therapeutic use : Antimetabolites, Antineoplastic, Deoxycytidine.
- geographic , epidemiology : Europe.
- drug therapy : Adenocarcinoma, Pancreatic Neoplasms.
- metabolism : Adenocarcinoma, Pancreatic Neoplasms.
- mortality : Adenocarcinoma, Pancreatic Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Treatment Outcome.
Abstract
Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection.
DOI: 10.1093/jnci/djt347
PubMed: 24301456
Affiliations:
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Le document en format XML
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Neoptolemos</name></author><author><name sortKey="Palmer, Daniel H" sort="Palmer, Daniel H" uniqKey="Palmer D" first="Daniel H" last="Palmer">Daniel H. Palmer</name></author><author><name sortKey="Cox, Trevor F" sort="Cox, Trevor F" uniqKey="Cox T" first="Trevor F" last="Cox">Trevor F. Cox</name></author><author><name sortKey="Lamb, Richard F" sort="Lamb, Richard F" uniqKey="Lamb R" first="Richard F" last="Lamb">Richard F. Lamb</name></author><author><name sortKey="Garner, Elizabeth" sort="Garner, Elizabeth" uniqKey="Garner E" first="Elizabeth" last="Garner">Elizabeth Garner</name></author><author><name sortKey="Campbell, Fiona" sort="Campbell, Fiona" uniqKey="Campbell F" first="Fiona" last="Campbell">Fiona Campbell</name></author><author><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R" last="Mackey">John R. Mackey</name></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name></author><author><name sortKey="Moore, Malcolm J" sort="Moore, Malcolm J" uniqKey="Moore M" first="Malcolm J" last="Moore">Malcolm J. Moore</name></author><author><name sortKey="Valle, Juan W" sort="Valle, Juan W" uniqKey="Valle J" first="Juan W" last="Valle">Juan W. Valle</name></author><author><name sortKey="Mcdonald, Alexander C" sort="Mcdonald, Alexander C" uniqKey="Mcdonald A" first="Alexander C" last="Mcdonald">Alexander C. Mcdonald</name></author><author><name sortKey="Carter, Ross" sort="Carter, Ross" uniqKey="Carter R" first="Ross" last="Carter">Ross Carter</name></author><author><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C" last="Tebbutt">Niall C. Tebbutt</name></author><author><name sortKey="Goldstein, David" sort="Goldstein, David" uniqKey="Goldstein D" first="David" last="Goldstein">David Goldstein</name></author><author><name sortKey="Shannon, Jennifer" sort="Shannon, Jennifer" uniqKey="Shannon J" first="Jennifer" last="Shannon">Jennifer Shannon</name></author><author><name sortKey="Dervenis, Christos" sort="Dervenis, Christos" uniqKey="Dervenis C" first="Christos" last="Dervenis">Christos Dervenis</name></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name></author><author><name sortKey="Deakin, Mark" sort="Deakin, Mark" uniqKey="Deakin M" first="Mark" last="Deakin">Mark Deakin</name></author><author><name sortKey="Charnley, Richard M" sort="Charnley, Richard M" uniqKey="Charnley R" first="Richard M" last="Charnley">Richard M. Charnley</name></author><author><name sortKey="Lacaine, Francois" sort="Lacaine, Francois" uniqKey="Lacaine F" first="François" last="Lacaine">François Lacaine</name></author><author><name sortKey="Scarfe, Andrew G" sort="Scarfe, Andrew G" uniqKey="Scarfe A" first="Andrew G" last="Scarfe">Andrew G. Scarfe</name></author><author><name sortKey="Middleton, Mark R" sort="Middleton, Mark R" uniqKey="Middleton M" first="Mark R" last="Middleton">Mark R. Middleton</name></author><author><name sortKey="Anthoney, Alan" sort="Anthoney, Alan" uniqKey="Anthoney A" first="Alan" last="Anthoney">Alan Anthoney</name></author><author><name sortKey="Halloran, Christopher M" sort="Halloran, Christopher M" uniqKey="Halloran C" first="Christopher M" last="Halloran">Christopher M. Halloran</name></author><author><name sortKey="Mayerle, Julia" sort="Mayerle, Julia" uniqKey="Mayerle J" first="Julia" last="Mayerle">Julia Mayerle</name></author><author><name sortKey="Olah, Attila" sort="Olah, Attila" uniqKey="Olah A" first="Attila" last="Oláh">Attila Oláh</name></author><author><name sortKey="Jackson, Richard" sort="Jackson, Richard" uniqKey="Jackson R" first="Richard" last="Jackson">Richard Jackson</name></author><author><name sortKey="Rawcliffe, Charlotte L" sort="Rawcliffe, Charlotte L" uniqKey="Rawcliffe C" first="Charlotte L" last="Rawcliffe">Charlotte L. Rawcliffe</name></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name></author><author><name sortKey="Bassi, Claudio" sort="Bassi, Claudio" uniqKey="Bassi C" first="Claudio" last="Bassi">Claudio Bassi</name></author><author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name></author></analytic><series><title level="j">Journal of the National Cancer Institute</title><idno type="eISSN">1460-2105</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term><term>Adenocarcinoma (metabolism)</term><term>Adenocarcinoma (mortality)</term><term>Adult</term><term>Aged</term><term>Antimetabolites, Antineoplastic (therapeutic use)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Biomarkers, Tumor (metabolism)</term><term>Deoxycytidine (analogs & derivatives)</term><term>Deoxycytidine (therapeutic use)</term><term>Disease-Free Survival</term><term>Equilibrative Nucleoside Transporter 1 (metabolism)</term><term>Europe (epidemiology)</term><term>Female</term><term>Fluorouracil (administration & dosage)</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Leucovorin (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Pancreatic Neoplasms (drug therapy)</term><term>Pancreatic Neoplasms (metabolism)</term><term>Pancreatic Neoplasms (mortality)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome (mortalité)</term><term>Adénocarcinome (métabolisme)</term><term>Adénocarcinome (traitement médicamenteux)</term><term>Antinéoplasiques antimétabolites (usage thérapeutique)</term><term>Désoxycytidine (analogues et dérivés)</term><term>Désoxycytidine (usage thérapeutique)</term><term>Estimation de Kaplan-Meier</term><term>Europe (épidémiologie)</term><term>Femelle</term><term>Fluorouracil (administration et posologie)</term><term>Humains</term><term>Leucovorine (administration et posologie)</term><term>Marqueurs biologiques tumoraux (métabolisme)</term><term>Mâle</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Transporteur équilibrant de nucléosides de type 1 (métabolisme)</term><term>Tumeurs du pancréas (mortalité)</term><term>Tumeurs du pancréas (métabolisme)</term><term>Tumeurs du pancréas (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Fluorouracil</term><term>Leucovorin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxycytidine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers, Tumor</term><term>Equilibrative Nucleoside Transporter 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimetabolites, Antineoplastic</term><term>Deoxycytidine</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Fluorouracil</term><term>Leucovorine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxycytidine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenocarcinoma</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adenocarcinoma</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénocarcinome</term><term>Marqueurs biologiques tumoraux</term><term>Transporteur équilibrant de nucléosides de type 1</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques antimétabolites</term><term>Désoxycytidine</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Survie sans rechute</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Anthoney, Alan" sort="Anthoney, Alan" uniqKey="Anthoney A" first="Alan" last="Anthoney">Alan Anthoney</name><name sortKey="Bassi, Claudio" sort="Bassi, Claudio" uniqKey="Bassi C" first="Claudio" last="Bassi">Claudio Bassi</name><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name><name sortKey="Campbell, Fiona" sort="Campbell, Fiona" uniqKey="Campbell F" first="Fiona" last="Campbell">Fiona Campbell</name><name sortKey="Carter, Ross" sort="Carter, Ross" uniqKey="Carter R" first="Ross" last="Carter">Ross Carter</name><name sortKey="Charnley, Richard M" sort="Charnley, Richard M" uniqKey="Charnley R" first="Richard M" last="Charnley">Richard M. Charnley</name><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><name sortKey="Cox, Trevor F" sort="Cox, Trevor F" uniqKey="Cox T" first="Trevor F" last="Cox">Trevor F. Cox</name><name sortKey="Deakin, Mark" sort="Deakin, Mark" uniqKey="Deakin M" first="Mark" last="Deakin">Mark Deakin</name><name sortKey="Dervenis, Christos" sort="Dervenis, Christos" uniqKey="Dervenis C" first="Christos" last="Dervenis">Christos Dervenis</name><name sortKey="Garner, Elizabeth" sort="Garner, Elizabeth" uniqKey="Garner E" first="Elizabeth" last="Garner">Elizabeth Garner</name><name sortKey="Ghaneh, Paula" sort="Ghaneh, Paula" uniqKey="Ghaneh P" first="Paula" last="Ghaneh">Paula Ghaneh</name><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name><name sortKey="Goldstein, David" sort="Goldstein, David" uniqKey="Goldstein D" first="David" last="Goldstein">David Goldstein</name><name sortKey="Greenhalf, William" sort="Greenhalf, William" uniqKey="Greenhalf W" first="William" last="Greenhalf">William Greenhalf</name><name sortKey="Halloran, Christopher M" sort="Halloran, Christopher M" uniqKey="Halloran C" first="Christopher M" last="Halloran">Christopher M. Halloran</name><name sortKey="Jackson, Richard" sort="Jackson, Richard" uniqKey="Jackson R" first="Richard" last="Jackson">Richard Jackson</name><name sortKey="Lacaine, Francois" sort="Lacaine, Francois" uniqKey="Lacaine F" first="François" last="Lacaine">François Lacaine</name><name sortKey="Lamb, Richard F" sort="Lamb, Richard F" uniqKey="Lamb R" first="Richard F" last="Lamb">Richard F. Lamb</name><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R" last="Mackey">John R. Mackey</name><name sortKey="Mayerle, Julia" sort="Mayerle, Julia" uniqKey="Mayerle J" first="Julia" last="Mayerle">Julia Mayerle</name><name sortKey="Mcdonald, Alexander C" sort="Mcdonald, Alexander C" uniqKey="Mcdonald A" first="Alexander C" last="Mcdonald">Alexander C. Mcdonald</name><name sortKey="Middleton, Mark R" sort="Middleton, Mark R" uniqKey="Middleton M" first="Mark R" last="Middleton">Mark R. Middleton</name><name sortKey="Moore, Malcolm J" sort="Moore, Malcolm J" uniqKey="Moore M" first="Malcolm J" last="Moore">Malcolm J. Moore</name><name sortKey="Neoptolemos, John P" sort="Neoptolemos, John P" uniqKey="Neoptolemos J" first="John P" last="Neoptolemos">John P. Neoptolemos</name><name sortKey="Olah, Attila" sort="Olah, Attila" uniqKey="Olah A" first="Attila" last="Oláh">Attila Oláh</name><name sortKey="Palmer, Daniel H" sort="Palmer, Daniel H" uniqKey="Palmer D" first="Daniel H" last="Palmer">Daniel H. Palmer</name><name sortKey="Rawcliffe, Charlotte L" sort="Rawcliffe, Charlotte L" uniqKey="Rawcliffe C" first="Charlotte L" last="Rawcliffe">Charlotte L. Rawcliffe</name><name sortKey="Scarfe, Andrew G" sort="Scarfe, Andrew G" uniqKey="Scarfe A" first="Andrew G" last="Scarfe">Andrew G. Scarfe</name><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><name sortKey="Shannon, Jennifer" sort="Shannon, Jennifer" uniqKey="Shannon J" first="Jennifer" last="Shannon">Jennifer Shannon</name><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C" last="Tebbutt">Niall C. Tebbutt</name><name sortKey="Valle, Juan W" sort="Valle, Juan W" uniqKey="Valle J" first="Juan W" last="Valle">Juan W. Valle</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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